HEPARIN-INDUCED THROMBOCYTOPENIA
Keywords:
heparin-induced thrombocytopenia, non-fractionated heparin, low molecular weight heparin, direct thrombin inhibitors, thrombotic complicationsAbstract
This review considers heparin-induced thrombocytopenia (HIT) – pathological condition that can develop when applying non-fractionated heparin (NFH). Due to insufficient knowledge and absence of required laboratory tests HIT is a rarely diagnosed condition in our clinics that influences on the adequate treatment of patients and prognosis. In vitro studies demonstrated that immune processes like forming HIT-antibodies and their interaction with heparin-tissue factor-4 complex and FcγRII-receptors on the platelets is the key moment in HIT. A big disadvantage is inability to get alternative anticoagulants. Management of hemorrhage in HIT especially without antidote is problematic. Applying heparins with low molecular weight and fondaparinux and direct thrombin inhibitors instead of NFH can result in that the HIT will become only a past history event.
Downloads
Issue
Section
License
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
