MODERN ASPECTS OF COMMUNITY-ACQUIRED PNEUMONIA IN PATIENTS WITH DIABETES MELLITUS
Abstract
Clinical importance of the community-acquired pneumonia clinical course and treatment in patients with diabetes mellitus is discussed in this review. Clinical characteristics, immunological parameters, possible drugs regimen, depending on community-acquired pneumonia severity, and the ability to optimize therapy with antibacterial drugs are considered. The features of the appointment of antibacterial drugs in the step-down antibacterial therapy, peculiarities of pneumonia in patients with diabetes mellitus.
Despite absence of specific guidelines for CAP treatment in patients with concomitant DM, this patients should be treated carefully because of: increased risk of infectious pathology, presence of the macro and micro complications of DM which can affect antibacterial drugs bioavailability and both diseases clinical course; pathological changes in immunity of DM patients with decreasing of immune reactivity to infectious agents; specific medication interactions between antibacterial drugs and glucose lowering agents as respiratory fluoroquinolones interactions with glucose lowering agents could lead to severe hypoglycemia; high risk of DM and CAP complication.
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Guidelines for the management of adult lower respiratory tract infections - Summary / Woodhead M., Blasi F., Ewig S. [et al.] // Clin. Microbiol. Infect. – 2011. – № 17 (6). – p. 1–24.
National Vital Statistics Reports Hyattsville, MD: National Center for Health Statistics [e- resurs] / Heron M. P., Hoyert D. L., Murphy S. L. [et al.] (2009) Deaths: Final data for 2006. – 2009. // Access link: http://www.cdc.gov/nchs/fastats/pneumonia.html
Kuznetsova L. F. Rational strategy of pharmacotherapy of patients with community-acquired pneumonia at elderly and senil eage / Kuznetsova L. F., Bogoslav T. V., Reshetilov Yu. I. // Zaporozhye medical journal. – 2014. – № 2. – p. 36–38
Kozlov R.S. Negospіtalna pnevmonіya: Standarti dіagnostiki, suchasna antibakterіalna terapіya / Kozlov R.S., Pertseva T.S., Dmitrichenko V.V. [et al.] // Ukrainsky medichny chasopis. – 2011. – № 6 (85). – p. 59–63.
Diabetes mellitus and infection: an evaluation of hospital utilization and management costs in the United States / Elsevier. - March 2015 // Access link: doi: http://dx.doi.org/10.1016/j.jdiacomp.2014.11.005
Bereznyakov I. G. Antibacterial pneumonia in patients with community-acquired pneumonia in the hospital / Bereznyakov I. G. // Clinical Immunology. Allergology. Infectology. – 2008. – № 5. - p. 22–26.
Community-acquired pneumonia in adults. Practice Guidelines for diagnosis, treatment and prevention: a manual for physicians / [Chuchalin A. G., Sinopalnikov A. I., Kozlov R. S. [et al.]. – M., 2010. – 106 p.
Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis / Fine M. J., Smith M. A., Carson C. A. [et al.] // JAMA. – 1996. – № 275. – p. 134–141.
Capelastegui A. Study of community-acquired pneumonia: incidence, patterns of care, and outcomes in primary and hospital care / Capelastegui A., Espaňa P.P., [et al.] // J. Infect. – 2010. – № 61. – p. 364–371.
The official website of the United Nations Organization / [electronic resource]. – Access link: http/www.un.org/russian.
Casqueiro J. Infections in patients with diabetes mellitus: A review of pathogenesis / Casqueiro J., Casqueiro J., Alves C. // Indian J Endocrinol Metab. – 2012 // Access link: doi: 10.4103/2230–8210.94253.
Endeman H. Systemic cytokine response in patients with community-acquired pneumonia / Endeman H., Meijvis S. C. A., Rijkers G. T. [et al.] // Eur. Respir. J. – 2011. – № 37. – p. 1431–1438.
Bereznyakov I.G. infections and antibiotics / Bereznyakov I.G. – Kh: Constant, 2004. – 447 p.
Stegenga M. E. Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis / Stegenga M. E., Vincent J. L., Vail G. M. [et al.] // Crit. Care Med. – 2009. – № 38. – p. 539–545.
Peleg A.Y. Common infections in diabetes: Pathogenesis, management and relationship to glycaemic control / Peleg A. Y., Weerarathna T., McCarthy J. S., Davis T.M. // Diabetes Metab Res Rev. – 2007. – № 23:3 – p. 13.
Nirmal J. Infections in patients with diabetes mellitus. / Nirmal J, Caputo GM, Weitekamp MR, Karchmer AW. // N Engl J Med. – 1999. – № 341. – p. 1906–12.
Vardakas K. Z. Diabetes mellitus as a risk factor for nosocomial pneumonia and associated mortality / Vardakas K. Z., Siempos I. I., Falagas M. E. // Diabet Med. – 2007. – №24. – p. 1168–71.
Geerlings S. E. Cytokine secretion is impaired in women with diabetes mellitus / Geerlings S.E., Brouwer E.C., Van Kessel K. C., Gaastra W., Stolk R. P., Hoepelman A. I. // Eur J Clin Invest. – 2000. - №30. – p. 995–1001.
Cano M, Iglesias P, Pérez G, Díez JJ. Influenza A virus (H1N1) infection as a cause of severe diabetic ketoacidosis in type 1 diabetes. Endocrinol Nutr. – 2010. – №57. – p. 37–8.
Aliberti S. Incidence, etiology, timing, and risk factors for clinical failure in hospitalized patients with community-acquired pneumonia / Aliberti S., Amir A., Peyrani P. [et al.] // Chest. – 2008. – № 134 (5). – p. 955–962.
Krogh-Madsen R. Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-{alpha}, and FFAs to low-dose endotoxemia in humans / Krogh-Madsen R., Moller K., Dela F. [et al.] // Am. J. Physiol. Endocrinol. Metab. – 2004. – № 286. – p. 766–772.
Stegenga M. E. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia / Stegenga M. E., van der Crabben S. N., Blümer R. M. [et al.] // Blood. – 2008. – № 112. – p. 82–89.
Avdeev S.N. C-reactive protein - new or old marker bronchopulmonary infections? / Avdeev S.N., Baymakanova G.E. // Atmosphere. Pulmonology and Allergology. – 2008. – № 4. – p. 26–32.
Baker E. H. Hyperglycemia and pulmonary infection. / Baker E. H., Wood D. M., Brennan A. L. [et al.] // Proc. Nutr. Soc. – 2006. – № 65. – p. 227–235.
Yende S. The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies / Yende S., van der Poll T., Lee M. J. [et al.] for the GenIMS and Health ABC study // Thorax. – 2010. – № 65. – p. 870–877.
Johnson E. L. Treatment of Diabetes in Long-Term Care Facilities: A Primary Care Approach / Johnson E. L., Brosseau J. D., Soule M., Kolberg J. // Clin. Diabetes. – 2008. – Vol. 26, № 4. – p. 152–156.
Niederman M. S. Recent advances in community-acquired pneumonia: inpatient and outpatient / Niederman M. S. // Chest. – 2007. – № 131. – p. 1205–1215.
Blasi F. Biomarkers in lower respiratory tract infections / Blasi F., Stolz D., Piffer F. // Pulmonary Pharmacology & Therapeutics. – 2010. – № 23. – p. 501–507.
Skopintsev M.A. Pathogenic aspects of the formation of a systemic inflammatory response in patients with community-acquired pneumonia: Abstract. Dis. for the degree of kand. med. nauk. Sciences: spec. 14.00.16 «Pathological physiology» / Skopintsev M. A. - Kemerovo, 2006. – 24 p.
Menendez R. Duration of length of stay in pneumonia: influence of clinical factors and hospital type / Menendez R., Cremades M. J., Martınez-Moragon E. [et al.] // Eur. Respir. J. – 2003. – № 22. – p. 643–648.
Bogun L. V. Infectious diseases in patients with diabetes mellitus / Bogun L. V. // Bolezni I antibiotiki. – 2009. – № 1 (1). – p. 24–29.
Saibal M. A. A. Community acquired pneumonia in diabetic and non-diabetic hospitalized patients: presentation, causative pathogens and outcome/ Saibal M. A. A., Rahman S. H. Z., Nishat L., Sikder N. H., Begum S. A., Islam M. J., Uddin K. N.// Bangladesh Med Res Counc Bull. – 2012. – № 38. – p. 98–103.
Ljubic S. Pulmonary infections in patients with diabetes / Ljubic S., Balachandran A., Pavlic-Renar I., Barada A., Metelko J. // Diabetologia Chroatica. – 2004. - № 33 (4). – p.115–124/
Edis E. C. Acinetobacter pneumonia: Is the outcome different from the pneumonias caused by other agents? / Edis E. C., Hatipoglu O. N., Tansel O., Sut N. // Annals of Thoracic Medicine. – 2010. – Vol.5 (2). – p. 92–96.
Schmidt N. V. The structure and antibiotic resistance of pathogens of community-acquired pneumonia in patients with diabetes mellitus type 2 // Clinical Microbiology and Antimicrobial Chemotherapy, abstracts of the XIV International Congress IACMAC / ESCMID for antimicrobial therapy. – 2012.
Thomsen R. W. Diabetes and Outcome of Community- Acquired Pneumococcal Bacteremia / Thomsen Reimar W., Johnsen Soren P. [et al.]. // Diabetes Care. – 2004. – № 27. – p. 70–76.
Ikegame S. A Retrospective Analysis of 111 Cases of Pneumococcal Pneumonia: Clinical Features and Prognostic Factors / Ikegame S., Wakamatsu K., Kumazoe1 H., Kawasaki M. // Intern Med. – 2012. – № 51. – p. 37–43.
Von Baum H. Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: diagnosis, incidence and predictors / von Baum H., Welte T., Marre R., Suttorp N., Ewig S.for the CAPNETZ study group // Eur Respir J. – 2010. – № 35. – p. 598–605.
Martins M. Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients / Martins M., Boavida J. M., Raposo J. F., Froes F., Nunes B., Ribeiro R. T., Macedo M. P., Penha-Gonçalves C. // BMJ Open Diab Res Care. – 2016. // Access link: doi:10.1136/bmjdrc-2015-00018
Labarere J. Comparison of Outcomes for Low-Risk Outpatients and Inpatients With Pneumonia : A Propensity-Adjusted Analysis / Labarere J., Stone R. A., Obrosky D. S., Yealy D. M. [et al.] // Chest. – 2007. – № 131. – p.480–488.
Kornum J. B. Type 2 diabetes and pneumonia outcomes: a population-based cohort study / Kornum J. B., Thomsen R. W., Riis A., Lervang H. H., Schønheyder H. C., Sørensen H. T. // Diabetes Care. – 2007. – № 30. – p.2251–225.
Kaplan V. Hospitalized community-acquired pneumonia in the elderly: age – and sex-related patterns of care and outcome in the United States / Kaplan V., Angus D. C., Griffin M. F. [et al.] // Am J Respir Crit Care Med. – 2002. – № 165. – p. 766–772.
Stegenga M. E. Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis / Stegenga M. E., Vincent J. L., Vail G. M. [et al.] // Crit Care Med. – 2009. – № 38. – p. 539–545.
Mandate №128 od 19.03.2007r. About zatverdzhennya klіnіchnih protokolіv nadannya medichnoї Relief for spetsіalnіstyu «Pulmonologіya» / Ministry of Health of Ukraine - Ofіts. vidannya – Singapore – 2007, 146 p. – (Normative documents of Ministry of Health of Ukraine).
Endeman H. Clinical features predicting failure of pathogen identification in patients with community acquired pneumonia / Endeman H., Schelfhout V., Voorn G. P. // Scandinavian Journal of Infectious Diseases. – 2008. – № 40. – p. 715–720.
Ewig S. New perspectives on community-acquired pneumonia in 388,406 patients. Results from a nationwide mandatory performance measurement programme in health-care quality / Ewig S., Birkner N., Strauss R., Schaefer E., Pauletzki J., Bischoff H., [et al.]. // Thorax. – 2009. – № 64. – p. 1062–1069.
Stralin K. Definite, probable and possible bacterial aetiologies of community-acquired pneumonia at different CRB-65 scores / Stralin K., Olcen P., Tornqvist E., Holmberg H. // Scandinavian Journal of Infectious Diseases. – 2010. – № 42. – p. 426–434.
Lim W. S. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. / Lim W. S., Macfarlane J. T., Boswell T. C., [et al.] // Thorax. – 2001. – № 56 (4). – p. 296–301.
Vnebol'nichnaya pnevmoniya u vzroslykh: prakticheskiye rekomendatsii po diagnostike, lecheniyu i profilaktike / Posobiye dlya vrachey // Rossiyskoye respiratornoye obshchestvo. – Moskva, 2010 g. – S. 1–106.
Lim W. S. 2015 - Annotated BTS Guideline for the management of CAP in adults (2009) / Lim W. S., Smith D. L., Wise M. P., Welham S. A. on behalf of the British Thoracic Society // Thorax. – 2015 // Access link: doi:10.1136/thoraxjnl-2015 –206881
Hai-yan Li. CUR-65 Score for Community-Acquired Pneumonia Predicted Mortality Better Than CURB-65 Score in Low–Mortality Rate Settings / Hai-yan Li, Qi Guo, Wei-dong Song [et all.] // 2015. – Access link: http://dx.doi.org/10.1097/MAJ.0000000000000545
Heppner H.J. Pneumonia Severity Index (PSI), CURB-65, and mortality in hospitalized elderly patients with aspiration pneumonia / Heppner H. J., Sehlhoff B., Niklaus D., Pientka L., Thiem U. // Z Gerontol Geriatr. – 2011. – № 44 (4). – p. 229–34.
Mazen S. Bader. Community-Acquired Pneumonia in Patients With Diabetes Mellitus: Predictors of Complications and Length of Hospital Stay / Mazen S. Bader [et al.] // Amer.Jour.of Science. – 2016. – Vol. 352, Issue 1. – p. 30–35.
Johns Hopkins Antibiotic Guidelines 2015-2016. Treatment Recommendations For Adult Inpatients. 2015. – p.64 // Access link: http://www.hopkinsmedicine.org/amp/guidelines/antibiotic_guidelines.pdf
Simonov S. S. Sequential therapy of bacterial respiratory infections in the practice of the family doctor / Simonov S. S. // Ukr.med.zhurnal. – 2014. – № 5 (103) – p. 40–46.
Bereznyakov I. G. Step-down therapy in the treatment of bacterial infections. : Questions and Answers / Bereznyakov I. G. // News of medits. and pharmacy. – 2011. – № 11–12. – p. 371–372.
Yudina L. V. The choice of antibiotic therapy with a combination of acute infections of the upper and lower respiratory tract. / Yudina L. V. // Ukrain. medy. Chasopis – 2013. – № 6 (98). – p. 43–46
Negospіtalna ta nozokomіalna (gospіtalna) pnevmonіya u doroslih osіb: klіnіchnі nastanovi, Ukraine // Health of Ukraine. – 2013. – № 18. – p. 35–37.
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