TREATMENT OF PREGNANT WOMEN INFECTED WITH SYPHILIS WITH INTRAVENOUS PENICILLIN G: PHARMACOKINETICAL AND CLINICAL STUDY
Abstract
Treatment of pregnant women infected with syphilis with intravenous infusions of penicillin G (2 million units every 12 hours) favors higher concentration of penicillin in blood serum (31 vs. 6-11 mkg/ml) and lower frequency and intensity of adverse effects (2.5 vs. 5.6%) in comparison with intramuscularly injections of benzyl penicillin (0.5–1.0 million units every 3 hours). Penicillin G favored a faster regress of clinical manifestations of syphilis (4-12 vs. 7-17 days) earlier obtaining negative results of serologic tests, more favorable outcomes of pregnancy if compared to group of patients who received benzyl penicillin. Thus, penicillin G is quite an effective medicine for treatment of pregnant women infected with syphilis.
Downloads
References
2. Калюжна ЛД. Захворювання, що передаються статевим шляхом, в Україні. // Український медичний альманах (Луганськ) 1999. № 2(1) (Додаток) C. 17-18.
3. Кияшко ГП. Сифіліс та вагітність.// Педіатрія, акушерство та гінекологія (ПАГ). 1998. V. 3. P. 123-130.
4. Дерев’янко ЛА. Аналіз захворюванності на уроджений сифіліс в Україні. // Журнал дерматологии и венерологии (Харьков) 2000. №1(9). С. 76-79.
5. Інструкція по лікуванню та профілактиці сифілісу і гонореї: Міністерство охорони здоров’я України. К., 1995. 48 С.
6. Борисенко КК, Лосева ОК, Доля ОВ: К вопросу о лечении сифилиса у беременных. ЗППП (Москва) 1997. № 5. С. 58-60.
7. Boatto G., Сerri R., Pau A. Et al. Monitoring of benzylpenicillin in ovine milk by HPLC // J. Pharmaceutic. Biomed. Anal. 1997. V. 17. P. 733-738.
8. Devore, Jay L. Probability and Statistics for Engineering and the Sciences. 4th ed. Wadsworth Publishing, 1995.
9. Беднова ВН, Новолоцкая ТИ, Миконова ТИ. Фармакокинетика пенициллина в эксперименте при изу-чении солей бензилпенициллина и бициллинов, вводимых изолированно и в сочетании с химотрипси-ном и лазиксом. // Вестник дерматологии и венерологии. 1991. № 6. С. 26-31.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.