COMPARATIVE EFFECTIVENESS OF AMLODIPIN MONOTHERAPY AT ADVANCED IN YEARS PATIENTS WITH ARTERIAL HYPERTENSION OF DIFFERENT DEGREES IN OUT-PATIENT STAGE
Keywords:
arterial hypertension, calcium channel blockers, quality of life, heart rate variability
Abstract
Forty six patients with arterial hypertension (AH) I-III stages were investigated in out-patient department. Estimated parameters were levels of systolic and diastolic blood pressures (SBP, DBP), heart rate, general index of quality of life (GIQL) and parameters of heart rate variability (total power (TP) and low- and high-frequency ratio (LF/HF)). Patients were evaluated before treatment, during the therapy and in acute pharmacological test with amlodipin. It was shown that all patients had signifficant increase of GIQL and decrease of TP. Effective decrease of SBP and DBP was found in patients with mild and moderate AH. Patients with severe AH had only depressed DBP. During the dynamic observation it was defined the decrease of total power in all patients’ groups and various LF/HF fluctuations.Downloads
Download data is not yet available.
References
1. Коркушко О.В., Саркисов К.Г., Забияка Л.К. и др. // Укр. кардіол. журн. - 2001. - № 4. - С. 43-48.
2. Жарінов О.Й. // Український кардіологічний журнал. - 2003. - № 1 (додаток). - С. 45-54.
3. Сіренко Ю.М. // Артеріальна гіпертензія. - 2002. - С. 48-49.
4. Сіренко Ю.М., Радченко Г.Д., Миронова О.В., и др. // Український кардіологічний журнал. - 2003 (додаток). - № 1. - С. 41-44.
5. Braunwald E. Heart disease: A textbook of Cardiovascular Medicine. Fifth Edition. USA. W.B. Saunders Company 1997.
6. Guidelines Committee. // J. Hypertension. - 2003. - Vol. 21. - P. 1011-1053.
7. Leenen F.H., Fourney A., Notman G., et al. // Brit. J. Clin. Pharmacology. - 1996. - Vol. 41. - P. 83-88.
8. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibi-tor or calcium channel blocker vs diuretic: The antihypertensive and Lipid-Lowering Treatment to Pre-vent Heart Attack Trial (ALLHAT) // JAMA. - 2002. - Vol. 288. - P. 2981-2997.
9. Pahor M., Psaty B.M., Alderman M.N., et al. // Lancet. - 2000. - Vol. 356. - P. 1949-1954.
10. Standards of measurment, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, (Membership of the Task Forcelisted in the Appendix) // Eur Heart J. - 1996. - № 17. - P. 354-81.
2. Жарінов О.Й. // Український кардіологічний журнал. - 2003. - № 1 (додаток). - С. 45-54.
3. Сіренко Ю.М. // Артеріальна гіпертензія. - 2002. - С. 48-49.
4. Сіренко Ю.М., Радченко Г.Д., Миронова О.В., и др. // Український кардіологічний журнал. - 2003 (додаток). - № 1. - С. 41-44.
5. Braunwald E. Heart disease: A textbook of Cardiovascular Medicine. Fifth Edition. USA. W.B. Saunders Company 1997.
6. Guidelines Committee. // J. Hypertension. - 2003. - Vol. 21. - P. 1011-1053.
7. Leenen F.H., Fourney A., Notman G., et al. // Brit. J. Clin. Pharmacology. - 1996. - Vol. 41. - P. 83-88.
8. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibi-tor or calcium channel blocker vs diuretic: The antihypertensive and Lipid-Lowering Treatment to Pre-vent Heart Attack Trial (ALLHAT) // JAMA. - 2002. - Vol. 288. - P. 2981-2997.
9. Pahor M., Psaty B.M., Alderman M.N., et al. // Lancet. - 2000. - Vol. 356. - P. 1949-1954.
10. Standards of measurment, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, (Membership of the Task Forcelisted in the Appendix) // Eur Heart J. - 1996. - № 17. - P. 354-81.
How to Cite
Anufrieva, L. (1). COMPARATIVE EFFECTIVENESS OF AMLODIPIN MONOTHERAPY AT ADVANCED IN YEARS PATIENTS WITH ARTERIAL HYPERTENSION OF DIFFERENT DEGREES IN OUT-PATIENT STAGE. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (9), 29-34. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7188
Issue
Section
Clinical research
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
