A REACTION OF HEART RATE VARIABILITY SPECTRAL PARAMETERS IN THE PHARMACOLOGICAL TEST WITH MEBICAR IN HEALTHY VOLUNTEERS

  • A. O. Radchenko V.N. Karazin Kharkiv National University, Kharkiv, Ukraine
  • S. A. S. Belal V.N. Karazin Kharkiv National University, Kharkiv, Ukraine
  • E. O. Nazarenko V.N. Karazin Kharkiv National University, Kharkiv, Ukraine
Keywords: mebicar, adaptogen, healthy volunteers, pharmacological test

Abstract

On 13 conditionally healthy volunteers aged from 18 to 46 years (mean age – 22±7,6 years) the variability of the total power (TP, ms2) of the spectrum, very low frequency (VLF, ms2), low frequency (LF, ms2) and high frequency (HF, ms2) domains of heart rate variability (HRV) in 5 minute intervals of ECG in I standard lead before and 30 minutes after oral admission of 500 mg of mebicar were evaluated. The data were processed by methods of nonparametric statistics. No significant changes in TP, VLF, LF, HF HRV after 30 minutes (maximum time declared by pharmacodynamics action) after administration of 500 mg of mebicar were noted by us. Accordingly, the effectiveness of mebicar as an adaptogen without evidence-based research cannot be postulated.

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Author Biographies

A. O. Radchenko, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine

 
S. A. S. Belal, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine

 
E. O. Nazarenko, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine

 

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Published
2016-11-17
How to Cite
Radchenko, A. O., Belal, S. A. S., & Nazarenko, E. O. (2016). A REACTION OF HEART RATE VARIABILITY SPECTRAL PARAMETERS IN THE PHARMACOLOGICAL TEST WITH MEBICAR IN HEALTHY VOLUNTEERS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (31), 29-31. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6354
Section
Clinical research