Synthesis of pyrimidine-2,4,6-trion and 2-thioxo-pyrimidin-4,6-dione with imidazolidine fragment

doi:10.26565/2220-637X-2013-22-05

Nadiia N. Kolos V.N. Karazin Kharkiv National University https://orcid.org/0000-0002-7520-656X
Dmitry I. Nikishin V.N. Karazin Kharkiv National University
Natalia V. Chechina V.N. Karazin Kharkiv National University
Lali L. Zamigaylo V.N. Karazin Kharkiv National University

DOI: https://doi.org/10.26565/2220-637X-2013-22-05

Keywords: N,N-dimethylbarbituric acid, thiobarbituric acid, aliphatic glyoxals, R-ureas, imidazolidine-2-ones, tetraazаspiro[5.5]undec-4-ene, one-pot synthesis

Abstract

Pyrimidine-2,4,6-trion (2-thioxopyrimidine-4,6-dione) with imidazolidine cycle in position 5 have been synthesized by the three-component condensation of aliphatic glyoxals, N,N-dimethylbarbituric (thiobarbituric) acid and ureas. Tetraazаspiro[5.5]undec-4-ene is shown to form in the reaction of N,N-dimethylbarbituric acid, hydrate glyoxal and N,N-dimethylurea.

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