Chlorpromazine interactions with lipid bilayers
Keywords:
lipid bilayer, chlorpromazine, Neutral Red, partition coefficientAbstract
The effect of cationic drug chlorpromazine (CPZ) on the structural state of model lipid membranes composed of zwitterionic phospholipid phosphatidylcholine (PC) and anionic phospholipid cardiolipin (CL) in molar ratios 8:2 and 3:2 has been investigated using the indicator dye Neutral Red (NR). CPZ incorporation into the PC/CL (8:2) liposomes led to the increase of NR partition coefficients. This effect was interpreted in terms of drug-induced membrane disordering. In contrast, CPZ association with PC/CL (3:2) lipid bilayers suppressed the dye partition which was assumed to be a result of lipid phase transition.
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Published
2006-06-05
Issue
Section
Cell biophysics
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How to Cite
Chlorpromazine interactions with lipid bilayers. (2006). Biophysical Bulletin, 1(17), 54-57. https://periodicals.karazin.ua/biophysvisnyk/article/view/12851
