Features of proteolytic processes in the breast tissue of different age patients with ductal carcinoma

Т. Ю. Лихолат
О. А. Лихолат
С. В. Антонюк

Keywords: breast cancer; proteolytic processes; tumor hormonal profile

Abstract

The proteolytic processes and hormonal profile as leading mechanisms of carcinogenesis, proliferation and invasion of breast tumors in of different age patients have been investigated. In breast tumors of premenopausal women there has been observed imbalance in protease-antiprotease system with subsequent changes of conformation and permeability of membranes, which negatively affects the response of estrogen and progesterone receptors, enhances proliferative potential and overexpression of Her-2/neu. These phenomena cause an increased risk of metastasis, invasion, aggressiveness and tumor recurrence. In postmenopausal women proteolysis has raised moderately, and inhibitory activity has enhanced, so tumors have been characterized by an average level of response of estrogen receptor and aggressiveness, and low proliferative potential, that stimulates tumor growth, but inhibits invasion and motility. At the same time, inhibition of proteolysis followed by slowing down the process of apoptosis results in tumor resistance to adjuvant therapy.

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References

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