Neuroplasticity And Cognitive Impairment In Patients With Bipolar Depression

Abstract

The pathogenesis of affective disorders has a complex multi-level character. In recent studies it was proved that in the depressive phase of bipolar affective disorder (BAD) there are observed violations of neuronal plasticity and macromorphological changes in brain regions that are responsible for cognitive functions. So, there is a close connection between the morphological and functional disorders in the marked areas and consequences of cognitive disorders in patients with BAD, such as impaired memory, attention and other things. Thus, improving neuroplasticity, we can indirectly affect depressive symptoms. The joint prescription of antidepressants and drugs that can directly improve metabolic processes in brain is promising in this respect. During the research we studied the approach to treatment of patients with depressive episode of BAR. It is proved that the use of pharmaceuticals which affect the brain’s neuroplasticity in patients with depressive phase of BAD significantly increases the efficiency of treatment and enlarges doctor’s therapeutic arsenal.