THE INFLUENCE OF DIPHTHERIA EXOTOXIN ON THE GROWTH KINETICS OF THE RFERENCE STRAINS OF MICROORGANISMS

Abstract

The growth kinetics of the reference strains of microorganisms under influence of the different doses of diphtheria exotoxin was studied. It was determined that the reaction of gram-negative bacteria and E.faecalis reference strain on diphtheria toxin presence in nutrient medium was the same – adding of diphtheria toxin in the nutrient medium in amount 0,1 ml on 1,0 ml resulted to the growth kinetics stimulation, but increasing of exotoxin concentration lead to inhibition of these strains growth kinetics. The accumulation of Candida fungi microbial mass under the exotoxin presence decreased as against control (р≤0,001). The growth of S.aureus reference strain suspended in the nutrient medium with smaller content of diphtheria toxin, while in the nutrient medium with greater amount of toxin partial lysis of S.aureus АТСС 25923 cells occurred.