Stochastic model for nmr analysis of multicomponent solutions of biologically active aromatic molecules

  • M. P. Evstigneev Department of Physics, Sevastopol National Technical University
  • V. P. Evstigneev Department of Physics, Sevastopol National Technical University
  • M. V. Shokurov Marine Hydrophysical Institute NASU
Keywords: hetero-association, multicomponent solution, NMR, dynamic equilibrium

Abstract

A mathematical description of the N-component mixture of interacting aromatic molecules in an aqueous solution has been suggested with a possibility to compute the observed NMR proton chemical shift for each of the dissolved molecular components (N-STOCH model). On the basis of the N-STOCH model, a computer algorithm for the calculation of dynamic equilibrium in the multicomponent mixture has been developed and validated against the three-component mixture of antibiotic daunomycin, vitamin B2, and caffeine.

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Author Biographies

M. P. Evstigneev, Department of Physics, Sevastopol National Technical University

Sevastopol 99053, Ukraine

V. P. Evstigneev, Department of Physics, Sevastopol National Technical University

Sevastopol 99053, Ukraine

M. V. Shokurov, Marine Hydrophysical Institute NASU

Sevastopol, Ukraine

References

Gale EF, Cundliffe E, Reynolds PE, Richmond MH, Waring MJ. The molecular basis of antibiotic action. 2nd ed. L: John Wiley; 1981. 500p.

Traganos F, Kapuscinski J, Darzynkiewicz Z. Cancer Res. 1991;51:3682.

Bedner E, Du L, Traganos F, Darzynkiemicz Z. Cytomery. 2001;43:38.

Dashwood R, Negishi T, Hayatsu H, Breinholt V, Hendricks J, Bailey G. Mutat. Res. 1998;399:245.

Wood AW, Sayer JM, Newmark HL, Yagi H, Michaud DP, Jerina DM, et al. Proc. Natl. Acad. Sci. USA. 1982;79:5122.

Raiczyk GB, Pinto J. Biochem. Pharm. 1988;37:1741.

Chu E, DeVita VT. Physicias’ cancer chemotherapy drug manual. L.: Jones and Bartleti Publ.; 2003. 512p.

Larsen RW, Jasuja R, Hetzler R, Muraoka PT, Andrada VG, Jameson DM. Biophys. J. 1996;70:443.

Davies DB, Veselkov DA, Djimant LN, Veselkov AN. Eur. Biophys. J. 2001;30:354.

Davies DB, Djimant LN, Veselkov AN. J. Chem. Soc. Faraday Trans. 1996;92:383.

Ribeiro L, Carvalho RA, Ferreira DC, Veiga FJB. Eur. J. Pharm. Sci. 2005;24(1).

Evstigneev MP, Evstigneev VP, Hernandez Santiago AA, Davies DB. Eur. J. Pharm. Sci. 2006.

Evstigneev MP, Mykhina YuV, Davies DB. Biophys. Chem. 2005;118:118.

Evstigneev MP, Rybakova KA, Davies DB. Biophys. Chem. 2006.

Veselkov AN, Evstigneev MP, Rogoav OV, Chubarov AS, Devis DB. Biofizika. 2004;49:587. (in Russian)

Evstigneev MP, Davies DB, Veselkov AN. Chem. Phys. 2006;321:25.

Veselkov AN, Evstigneev MP, Veselkov DA, Davies DB. J. Chem. Phys. 2001;115:2252.

Iton RDzh,Veselko DA,Baranovskii SF, Osetrov SG, Dymant LN, Devis DB, et al. Khim. fizika. 2001;9:98. (in Russian)

Evstigneev MP, Rozvadovskaia AO, Chubarov AS, Ernandes Santiago AA, Devis DB, Veselkov AN. Zhurn. struktur. khimi. 2005;46:70. (in Russian)

Evstigneev MP, Rozvadovskaia AO, Ernandes Santiago aA, Mukhina IuV, Veselkov KA, et al. Fikz. khimiia. 2005;79:673. (in Russian)
Published
2005-06-06
Cited
How to Cite
Evstigneev, M. P., Evstigneev, V. P., & Shokurov, M. V. (2005). Stochastic model for nmr analysis of multicomponent solutions of biologically active aromatic molecules. Biophysical Bulletin, 2(16), 10-14. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/13286