TY - JOUR AU - Arkhypova, K. А. AU - Krasov, P. S. AU - Fisun, A. I. PY - 1970/01/01 Y2 - 2024/03/28 TI - Application of modified waveguide sensor for dielectric study of red blood cells of patients with discirculatory encephalopathy before and after the therapy JF - Biophysical Bulletin JA - Bioph. Bull. VL - 2 IS - 27 SE - Methods of biophysical investigations DO - UR - https://periodicals.karazin.ua/biophysvisnyk/article/view/2545 SP - AB - The paper describes the EHF dielectrometry method which is used for study of dielectric characteristicsof human red blood cells (RBCs) in the free water dispersion region. This method is based onmeasurement of complex reflection coefficient from short-circuit multilayer structure (waveguide sensor)containing the sample in the single-frequency mode (39.5 GHz). An improved in their accuracycharacteristics waveguide sensor has been used. For a given sensor the problem of finding the complexpermittivity has been solved for the first time and realized by solving the direct and inverse problems ofelectrodynamics using numerical methods. The direct problem of finding the complex reflectioncoefficient was solved by the finite-difference time-domain (FDTD) method. This method makes itpossible simulating the measuring structures of arbitrary shape containing the sample under study. Theinverse problem is implemented by solving a system of nonlinear equations. The algorithm developed hasbeen successfully applied by the authors for the sensor calibration, which allowed use in the study of thedielectric characteristics of the blood. As an example of feasible application of improved sensor theresults of measurement dielectric characteristics of RBCs of patients with discirculatory encephalopathybefore and after therapy are represented. It has been revealed an increasing their complex permittivity,which indicates a change of water state in the cells in the dynamics of therapy. There was a significantincrease in the complex permittivity, which indicates a change of water state in the cells as a result ofmedical treatment. The data obtained demonstrates the opportunity of using EHF dielectrometry whileevaluating the state of the patient’s blood cells during their rehabilitation. ER -