@article{Gladkovskaya_2007, title={The analysis of interaction of the biologically active ligands to nucleic acids}, volume={2}, url={https://periodicals.karazin.ua/biophysvisnyk/article/view/17143}, abstractNote={<p>The work is dedicated to a literature review of interactions of biologically active ligands with nucleic acid molecules. The structural and thermodynamic parameters of DNA - ligand binding are considered. The binding mechanisms for intercalation and groove binding drug to DNA have been examined. Analysis of such literature-based thermodynamic data revealed different thermodynamic parameters for groove-binding and intercalating compounds. The new approach of identifying the different types of binding due to thermodynamic signatures ΔG, ΔH, ΔS is discussed.</p&gt;}, number={19}, journal={Biophysical Bulletin}, author={Gladkovskaya, N. A.}, year={2007}, month={Jun.}, pages={55-64} }