Apoptosis of enterocytes in chronic carrageenan-induced gastroenterocolitis: a study by fluorescent probes
Keywords:
enterocytes, biomembrane, carrageenan, fluorescent probeAbstract
A study of the lipid bilayer of membranes of enterocytes of rats with chronic gastroenterocolitis was performed in this work. For the study we used fluorescent probes – ortho-hydroxy derivatives of oxazole, molecules of which bind non-covalently to the membranes of cells and respond to changes in the microenvironment. It has been found that during the course of chronic carrageenan-induced gastroenterocolitis an increase in hydration of the polar regions of enterocyte membranes occurs. The increase in hydration is attributed to the activation of enterocytes apoptosis. It has been shown that a fluorescent probe (2-(2¢-OH-phenyl)-5-phenyl-1,3-oxazole) can be used for the detection of apoptosis of enterocytes.
Downloads
Issue
Section
License
Authors retain copyright of their work and grant the journal the right of its first publication under the terms of the Creative Commons Attribution License 4.0 International (CC BY 4.0), that allows others to share the work with an acknowledgement of the work's authorship.
Authors are permitted to enter into additional non-exclusive agreements for the distribution of the published version of their work (for example, depositing it in institutional repositories or including it in collections), provided that the original publication in this journal is properly acknowledged.
