Activity of aldehyde catabolism enzymes in postmitochondrial fraction of femoral muscle of rats of different ages
Keywords:
skeletal muscle; aldehydes; aldehyde dehydrogenase; aldehyde reductase; glutathione transferase; postmitochondrial fraction; ontogenesisAbstract
The aim of this work is investigation of activity of endogenous aldehydes catabolism enzymes in postmitochondrial fraction of intact and immobilized rats of different age. We have revealed that optimal conditions for utilization of carbonyl products of free radical oxidation form in postmitochondrial fraction of femoral muscle in adult and old rats. It is a result of high basal activity enzymes of endogenous aldehydes catabolism. The same situation takes place during prolonged immobilized stress in adult and old rats. The restriction of basal activity of these enzymes and peculiarities in their modulation during prolonged immobilization lead to accumulation of endogenous aldehydes in muscle tissue and its stress injury at pubertal rats.
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