DEVELOPMENT AND PROGRESSION OF OBESITY IN PATIENTS WITH CORONARY HEART DISEASE: EMPHASIS ON LEPTIN GENE POLYMORPHISM (Arg223Gln)

  • P. G. Kravchun Kharkiv National Medical University https://orcid.org/0000-0002-8285-6763
  • O. I. Kadykova Kharkiv National Medical University
  • O. I. Zalyubovs'ka Kharkiv National Medical University
  • N. V. Shumova Kharkiv National Medical University
Keywords: leptin gene polymorphism, obesity, coronary heart disease

Abstract

The article assesses the contribution of leptin gene polymorphism (Arg223Gln) in the development and progression of obesity in patients with coronary heart disease. 222 patients with coronary heart disease and obesity were surveyed. The study of leptin gene polymorphic locus Arg223Gln was performed by polymerase chain reaction of all examined patients. G allele and G/G genotype of the leptin gene polymorphism (Arg223Gln) are more common among the patients with coronary heart disease and obesity and the frequency of their detection increases with the growth of the degree of obesity.

G allele and G/G genotype of leptin gene polymorphism (Arg223Gln) were associated with the development of obesity in CHD patients, and the frequency of their detection increases with the growth of BMI in the Ukrainian population.Given the urgency of the comorbid pathology problem further research should be directed towards the study of other associations of gene polymorphisms with the development and progression of cardiovascular diseases and obesity.

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Author Biographies

P. G. Kravchun, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

O. I. Kadykova, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

O. I. Zalyubovs'ka, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

N. V. Shumova, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

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Published
2017-12-28
How to Cite
Kravchun, P. G., Kadykova, O. I., Zalyubovs’ka, O. I., & Shumova, N. V. (2017). DEVELOPMENT AND PROGRESSION OF OBESITY IN PATIENTS WITH CORONARY HEART DISEASE: EMPHASIS ON LEPTIN GENE POLYMORPHISM (Arg223Gln). The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (34), 7-10. https://doi.org/10.26565/2227-6505-2017-34-02