L. V. Bogun, F. Lawal Wuraola, O. O. Ivleva, O. O. Okhryamkina


The article emphasizes the necessity of meticulous physical examination of the patient in the modern clinical practice. Two clinical examples of diagonal earlobe crease, also known as Frank’s sign, are given. Both cases describe patients with ischemic heart disease, but age of patients and severity of Frank’s sign differ. The literature data about its frequency in different groups of population as well as the clinical significance and possible underlying pathophysiological mechanisms of Frank’s are shown.


diagonal earlobe crease, Frank’s sign, atherosclerosis

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